| Gene Symbol | UBE2I |
| Full Name | Ubiquitin-Conjugating Enzyme E2 I |
| Aliases | SUMO-Conjugating Enzyme |
| Chromosome | 16p13.3 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain with high levels in hippocampus, cortex, and basal ganglia |
| Subcellular Localization | </strong></td><td>Nucleus, Cytoplasm</td></tr> |
| Molecular Weight | 18 kDa |
| UniProt ID | [P63279](https://www.uniprot.org/uniprot/P63279) |
| Ensembl ID | ENSG00000184254 |
| OMIM | 601231 |
| GeneCards | UBE2I |
| Human Protein Atlas | UBE2I |
| C-terminal Tail | Unlike other E2 enzymes, UBE2I has an extended C-terminal tail that contains the catalytic cysteine and contributes to SUMO recognition. This tail is essential for SUMO conjugation specificity. |
| Associated Diseases | neurodegeneration |
| Interactions | ATF3 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!