Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SENP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | SENP2 |
| Full Name | SUMO Specific Peptidase 2 |
| Aliases | Page for SENP2 Protein |
| Protein Type | Protease |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 68 kDa |
| Amino Acids | 589 aa |
| Pathways | Wnt |
| UniProt ID | [Q9Y2W1](https://www.uniprot.org/uniprot/Q9Y2W1) |
| GeneCards | SENP2 |
| Human Protein Atlas | SENP2 |
| SUMO-2/3 processing | Prefers SUMO-2 and SUMO-3 precursors |
| Chain editing | Efficiently processes SUMO-2/3 chains |
| Spatial restriction | Functions at the nuclear envelope |
| RANGAP1 processing | Critically processes RANGAP1 for RanGAP1 SUMOylation |
| Associated Diseases | neurodegeneration |
| Interactions | ATF3 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SENP2["SENP2"]
Als{"Als"}
SENP2 -->|"expressed in"| Als
Ms{"Ms"}
SENP2 -->|"expressed in"| Ms
UBE2I["UBE2I"]
SENP2 -->|"expressed in"| UBE2I
neurodegeneration["neurodegeneration"]
SENP2 -->|"implicated in"| neurodegeneration
TP53["TP53"]
TP53 -->|"expressed in"| SENP2
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"expressed in"| SENP2
P53["P53"]
P53 -->|"expressed in"| SENP2
ATF3["ATF3"]
ATF3 -->|"activates"| SENP2
style SENP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SENP2 in their description or question text
No additional research found