gene

TUBB2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBB2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

6Outgoing

12Incoming

0Experiments

0Debates

Summary

TUBB2B encodes a neuron-specific beta-tubulin critical for cortical development, neuronal migration, and microtubule function in neurodegeneration.

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🧬 Gene Info

Gene Symbol	TUBB2B
Full Name	Tubulin Beta 2B Class IIb[@jagadeesh2023]
Chromosome	6p25.3
Primary Expression	Brain, primarily during development
Molecular Weight	50 kDa
Amino Acids	445 aa
UniProt ID	Q9BUF5
Ensembl ID	ENSG00000159339
GeneCards	TUBB2B
Human Protein Atlas	TUBB2B
Associated Diseases	ALS, Alzheimer, dementia, frontotemporal, neurodegeneration
KG Connections	18 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TUBB2B — AlphaFold Q9BUF5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TUBB2B — Tubulin Beta 2B Class IIb

gene · 2334 words

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TUBB2B Protein

protein · 1592 words

→

Pathway Diagram

graph TD
    TUBB2B["TUBB2B"] -->|"associated_with"| dementia["dementia"]
    TUBB2B["TUBB2B"] -->|"associated_with"| neurodegeneration["neurodegeneration"]
    TUBB2B["TUBB2B"] -->|"associated_with"| frontotemporal["frontotemporal"]
    TUBB2B["TUBB2B"] -->|"associated_with"| Alzheimer["Alzheimer"]
    TUBB2B["TUBB2B"] -->|"associated_with"| ALS["ALS"]
    SYNPO["SYNPO"] -->|"co_expressed_with"| TUBB2B["TUBB2B"]
    TARDBP["TARDBP"] -->|"co_expressed_with"| TUBB2B["TUBB2B"]
    style TUBB2B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
neurodegeneration	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
synaptic plasticity	participates_in	pathway	0.60
dementia	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
ALS	associated_with	disease	0.60

Incoming (12)

Source	Relation	Type	Str
FTLD	implicated_in	gene	0.60
SLC1A2	implicated_in	gene	0.60
SYNPO	implicated_in	gene	0.60
CADM1	implicated_in	gene	0.60
COMT	implicated_in	gene	0.60
ITPKA	implicated_in	gene	0.60
LRFN1	implicated_in	gene	0.60
NCAN	implicated_in	gene	0.60
RAB3B	implicated_in	gene	0.60
RNA	implicated_in	gene	0.60
TARDBP	co_expressed_with	gene	0.50
SYNPO	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TUBB2B in their description or question text

No additional research found