Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRIM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| MAP1LC3B2 | regulates | gene | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TRIM21 as a 'Phase Separation Thermostat' via Catalytic Reve | 0.700 | neurodegeneration | How does TRIM21-mediated K63 ubiquitinat |
| ALS-Associated G3BP1/2 Mutations Disrupt TRIM21 Binding Inte | 0.585 | neurodegeneration | How do pathological stress granules in n |
| TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gr | 0.548 | neurodegeneration | What determines the spatial organization |
| Hyperphosphorylated TDP-43 Traps TRIM21 Into Inactive Comple | 0.487 | neurodegeneration | How do pathological stress granules in n |
| Casein Kinase 2 (CK2)-Mediated Hyperphosphorylation of G3BP1 | 0.440 | neurodegeneration | How do pathological stress granules in n |
Scientific analyses that reference this entity
molecular biology | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.633
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730
neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.717
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TRIM21 E3 ubiquitin ligase screen for stress granule regulation | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.75 · 2026-04-22
closed · Rounds: 4 · Score: 0.79 · 2026-04-21
closed · Rounds: 4 · Score: 0.69 · 2026-04-21
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
Hypotheses and analyses mentioning TRIM in their description or question text
No additional research found