| Gene Symbol | TRIM63 |
| Protein Type | Ligase |
| Function | TRIM63 (Tripartite Motif Containing 63), also known as MURF-1 (Muscle-Specific RING Finger Protein 1), is a muscle-specific E3 ubiquitin ligase that plays a critical role in protein degradation pathwa |
| Pathways | mTOR signaling, NF-κB |
| Ensembl ID | ENSG00000146070 |
| GeneCards | TRIM63 |
| Human Protein Atlas | TRIM63 |
| Myosin heavy chain (MyHC) | Structural protein in muscle fibers 2 |
| Troponin I | Regulatory protein in muscle contraction |
| Titin | Large protein responsible for muscle elasticity |
| Nuclear proteins | Involved in gene regulation |
| LC3 interaction | Can bind to autophagy-related proteins 4 |
| Selective autophagy | Targets damaged proteins for autophagic degradation |
| Mitophagy | May influence mitochondrial quality control in muscle |
| Skeletal muscle | Highest expression in fast-twitch (type II) fibers |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!