gene

TLR8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TLR8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

0Analyses

11Outgoing

9Incoming

0Experiments

0Debates

Summary

TLR8 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, implicated in. Associated with Inflammation, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TLR8
Full Name	Toll-Like Receptor 8
Chromosome	Xp22.2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	myeloid cells and recognizes single-stranded RNA (ssRNA) from viruses as well as synthetic antiviral compounds
Molecular Weight	110 kDa
Amino Acids	200 aa
Pathways	MAPK
UniProt ID	[Q9NYK5](https://www.uniprot.org/uniprot/Q9NYK5)
Ensembl ID	ENSG00000101916
OMIM	300366
GeneCards	TLR8
Human Protein Atlas	TLR8
Leucine-rich repeat (LRR) domain	Consists of 25 LRR motifs that form the ligand-binding region
Associated Diseases	Ms
Interactions	AND, IL-6, INFLAMMATION, LIPOPHAGY, MTOR, RAB7A
KG Connections	20 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TLR8 Gene

gene · 1533 words

→

TLR8 Protein

protein · 592 words

→

Pathway Diagram

graph TD
    TLR8["TLR8"]
    Ms{"Ms"}
    TLR8 -->|"inhibits"| Ms
    Inflammation{"Inflammation"}
    TLR8 -->|"inhibits"| Inflammation
    INFLAMMATION["INFLAMMATION"]
    TLR8 -->|"inhibits"| INFLAMMATION
    LIPOPHAGY["LIPOPHAGY"]
    TLR8 -->|"inhibits"| LIPOPHAGY
    Lipid_Metabolism(["Lipid Metabolism"])
    TLR8 -->|"inhibits"| Lipid_Metabolism
    Toll_Like_Receptor(["Toll-Like Receptor"])
    TLR8 -->|"activates"| Toll_Like_Receptor
    Mtor(["Mtor"])
    TLR8 -->|"activates"| Mtor
    neurodegeneration["neurodegeneration"]
    TLR8 -->|"implicated in"| neurodegeneration
    MTOR["MTOR"]
    MTOR -->|"activates"| TLR8
    RAB7A["RAB7A"]
    RAB7A -->|"activates"| TLR8
    style TLR8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Inflammation	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	causes	disease	0.65
Toll-Like Receptor	activates	pathway	0.60
Mtor	activates	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
TLR9	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TLR3	activates	gene	0.60
LIPOPHAGY	inhibits	gene	0.60
Lipid Metabolism	inhibits	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
AND	activates	gene	0.60
MTOR	activates	gene	0.60
RAB7A	activates	gene	0.60
TNF	activates	gene	0.60
TLR7	activates	gene	0.60
IL-6	activates	gene	0.60
TNF-Α	activates	gene	0.60
IFN	causes	gene	0.60
TLR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TLR8 in their description or question text

No additional research found