protein

SIGMA-1 RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGMA-1 RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

1Hypotheses

1Analyses

7Outgoing

9Incoming

0Experiments

1Debates

Summary

Page for Sigma-1 Receptor Protein

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🔬 Protein Info

Gene Symbol	SIGMA
Full Name	1 RECEPTOR
Molecular Weight	25.3 kDa
Pathways	Gut Microbiota, Microbiota
GeneCards	SIGMA
Human Protein Atlas	SIGMA
Interactions	ANXIETY, BDNF, CREB, SIGMAR1, TRKB
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    SIGMA_1_RECEPTOR("SIGMA-1 RECEPTOR")
    ANXIETY["ANXIETY"]
    SIGMA_1_RECEPTOR -->|"inhibits"| ANXIETY
    Hippocampus["Hippocampus"]
    SIGMA_1_RECEPTOR -->|"inhibits"| Hippocampus
    Microbiota["Microbiota"]
    SIGMA_1_RECEPTOR -->|"activates"| Microbiota
    Gut_Microbiota["Gut Microbiota"]
    SIGMA_1_RECEPTOR -->|"activates"| Gut_Microbiota
    CENTRAL_NERVOUS_SYSTEM["CENTRAL NERVOUS SYSTEM"]
    SIGMA_1_RECEPTOR -->|"expressed_in"| CENTRAL_NERVOUS_SYSTEM
    DEPRESSION{"DEPRESSION"}
    DEPRESSION -->|"inhibits"| SIGMA_1_RECEPTOR
    BDNF["BDNF"]
    BDNF -->|"inhibits"| SIGMA_1_RECEPTOR
    TRKB["TRKB"]
    TRKB -->|"inhibits"| SIGMA_1_RECEPTOR
    SIGMAR1["SIGMAR1"]
    SIGMAR1 -->|"inhibits"| SIGMA_1_RECEPTOR
    DEPRESSION -->|"activates"| SIGMA_1_RECEPTOR
    BDNF -->|"activates"| SIGMA_1_RECEPTOR
    CREB("CREB")
    CREB -->|"activates"| SIGMA_1_RECEPTOR

Outgoing (7)

Target	Relation	Type	Str
BDNF	regulates	gene	0.80
Endoplasmic reticulum chaperone protein expression	regulates	process	0.70
ANXIETY	inhibits	gene	0.50
Hippocampus	inhibits	entity	0.50
Microbiota	activates	process	0.50
Gut Microbiota	activates	process	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50

Incoming (9)

Source	Relation	Type	Str
BDNF	regulates	gene	0.80
Trazodone	activates	drug	0.70
DEPRESSION	inhibits	disease	0.50
BDNF	inhibits	gene	0.50
TRKB	inhibits	gene	0.50
SIGMAR1	inhibits	gene	0.50
DEPRESSION	activates	disease	0.50
BDNF	activates	gene	0.50
CREB	activates	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sigma-1 Receptor-Mediated UPR Reset as Primary Disease-Modif	0.605	-	What is the minimum effective dose of tr

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the minimum effective dose of trazodone required for disease-modifying e

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.605

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the minimum effective dose of trazodone required for disease-modifying e

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning SIGMA-1 RECEPTOR in their description or question text

No additional research found