protein

SYNJ1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNJ1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Synaptojanin 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	SYNJ1PROTEIN
Chromosome	21q22.11
Protein Type	Phosphatase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	</b></td><td>Presynaptic terminal, cytosol</td></tr>
Molecular Weight	173 kDa
GeneCards	SYNJ1PROTEIN
Human Protein Atlas	SYNJ1PROTEIN
N-terminal Sac1 domain	Phosphatase domain with broad specificity for phosphoinositides
Central Sac3 domain	Additional phosphatase activity
C-terminal proline-rich region	Interactions with endocytic proteins via SH3 domains
C-terminal region	Autoinhibitory sequences
Basal ganglia	Striatum (medium spiny neurons)
Cerebellum	Purkinje cells
Brainstem	Pontine nuclei and inferior olive
Associated Diseases	Als, Cancer, Ms, Parkinson
Interactions	AD, ATP13A2, BIN1, DJ1, DNAJC6, FBXO7
KG Connections	119 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Synaptojanin 1 Protein

protein · 885 words

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Pathway Diagram

graph TD
    SYNJ1PROTEIN["SYNJ1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    SYNJ1PROTEIN -->|"implicated_in"| neurodegeneration
    style SYNJ1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SYNJ1PROTEIN in their description or question text

No additional research found