| Gene Symbol | SYNJ1PROTEIN |
| Chromosome | 21q22.11 |
| Protein Type | Phosphatase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | </b></td><td>Presynaptic terminal, cytosol</td></tr> |
| Molecular Weight | 173 kDa |
| GeneCards | SYNJ1PROTEIN |
| Human Protein Atlas | SYNJ1PROTEIN |
| N-terminal Sac1 domain | Phosphatase domain with broad specificity for phosphoinositides |
| Central Sac3 domain | Additional phosphatase activity |
| C-terminal proline-rich region | Interactions with endocytic proteins via SH3 domains |
| C-terminal region | Autoinhibitory sequences |
| Basal ganglia | Striatum (medium spiny neurons) |
| Cerebellum | Purkinje cells |
| Brainstem | Pontine nuclei and inferior olive |
| Associated Diseases | Als, Cancer, Ms, Parkinson |
| Interactions | AD, ATP13A2, BIN1, DJ1, DNAJC6, FBXO7 |
| KG Connections | 119 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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