gene

SCA7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

9Outgoing

7Incoming

0Experiments

0Debates

Summary

Page for SCA7 Gene

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🧬 Gene Info

Gene Symbol	SCA7
Full Name	ATXN7 (Ataxin-7)
Chromosome	3p12
Protein Type	Transferase
Function	is a 892-amino acid protein with several distinct functional domains
Amino Acids	892 aa
Exons	13
UniProt ID	[Q9UQ50](https://www.uniprot.org/uniprotkb/Q9UQ50/entry)
GeneCards	SCA7
Human Protein Atlas	SCA7
Histone acetylation	Through the GCN5 acetyltransferase activity
Histone deubiquitination	Through the USP22 deubiquitinase activity
Transcriptional activation	By bridging transcription factors with the basal transcriptional machinery
Associated Diseases	Ataxia
Interactions	ATG12
KG Connections	16 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCA7 Gene

gene · 2779 words

→

Spinocerebellar Ataxia Type 7 (SCA7)

disease · 3321 words

→

Pathway Diagram

flowchart TD
    SCA7(["SCA7"])
    Ataxia["Ataxia"]
    Neurodegeneration["Neurodegeneration"]
    NEURODEGENERATION(["NEURODEGENERATION"])
    NEURODEGENERATIVE_DISEASES(["NEURODEGENERATIVE DISEASES"])
    neurodegeneration["neurodegeneration"]

    SCA7 -->|"associated with"| Ataxia
    SCA7 -->|"therapeutic target"| Neurodegeneration
    SCA7 -->|"therapeutic target"| NEURODEGENERATION
    SCA7 -->|"causes"| NEURODEGENERATIVE_DISEASES
    SCA7 -->|"implicated in"| neurodegeneration

    style SCA7 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (9)

Target	Relation	Type	Str
Ataxia	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
NEURODEGENERATION	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
SPG7	regulates	gene	0.60
SPG7	co_expressed_with	gene	0.60
neurodegeneration	regulates	disease	0.60
neurons	expressed_in	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (7)

Source	Relation	Type	Str
RAN	associated_with	gene	0.60
SCA3	associated_with	gene	0.60
LAMP2	biomarker_for	gene	0.60
LC3	biomarker_for	gene	0.60
ATG12	interacts_with	gene	0.60
SCA3	regulates	gene	0.60
SCA3	co_expressed_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCA7 in their description or question text

No additional research found