| Gene Symbol | RAB3C |
| Chromosome | 22 |
| Function | The RAB3C (RAB3C, Member RAS Oncogene Family) gene encodes a member of the Rab GTPase family, which is part of the Ras superfamily of small GTPases |
| Primary Expression | neuronal and neuroendocrine tissues, where it plays essential roles in regulated secretion, synaptic vesicle trafficking, and neurotransmitter release |
| Molecular Weight | 30 kDa |
| Exons | Multiple exons spanning approximately 20 kb |
| Pathways | Glycolysis |
| Ensembl ID | ENSG00000172985 |
| GeneCards | RAB3C |
| Human Protein Atlas | RAB3C |
| Location | 22q12.3 |
| Transcript | Protein-coding gene with multiple splice variants |
| Promoter | Contains neuron-specific regulatory elements |
| GTP-binding domain (G-domain) | Consists of five highly conserved G motifs (GxxxxGKST, DxxG, NKXD, T/SAK, WDTAGLE) that mediate nucleotide binding and hydrolysis |
| Switch I region | Undergoes dramatic conformational change upon GTP/GDP exchange, mediates effector protein binding |
| Associated Diseases | Als |
| Interactions | ATP, Il-6, Stat3 |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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