protein

PRNPPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRNPPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The prion protein (PrP) represents one of the most fascinating and enigmatic molecules in neurobiology.

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🔬 Protein Info

Gene Symbol	PRNPPROTEIN
Full Name	Major prion protein (PrP^c)
Chromosome	20p13
Function	is a glycosylphosphatidylinositol (GPI)-anchored protein that plays a central role in prion diseases.
Molecular Weight	~33-35 kDa (unglycosylated)
Amino Acids	253 amino acids
UniProt ID	P04156
GeneCards	PRNPPROTEIN
Human Protein Atlas	PRNPPROTEIN
Associated Diseases	Aging, Als, Alzheimer, Creutzfeldt-Jakob, frontotemporal dementia
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, APP, BACE1, BDNF, CTSB
KG Connections	111 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PRNPPROTEIN — AlphaFold P04156 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Prion Protein

protein · 3290 words

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Pathway Diagram

graph TD
    PRNPPROTEIN["PRNPPROTEIN"]
    neurodegeneration["neurodegeneration"]
    PRNPPROTEIN -->|"implicated_in"| neurodegeneration
    style PRNPPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRNPPROTEIN in their description or question text

No additional research found