protein 3,290 words KG: PRNPPROTEIN
Contents

Prion Protein

🔬 Protein Info
Gene SymbolPRNPPROTEIN
Full NameMajor prion protein (PrP^c)
Chromosome20p13
Functionis a glycosylphosphatidylinositol (GPI)-anchored protein that plays a central role in prion diseases.
Molecular Weight~33-35 kDa (unglycosylated)
Amino Acids253 amino acids
UniProt IDP04156
GeneCardsPRNPPROTEIN
Human Protein AtlasPRNPPROTEIN
Associated DiseasesAging, Als, Alzheimer, Creutzfeldt-Jakob, frontotemporal dementia
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, APP, BACE1, BDNF, CTSB
KG Connections110 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (5)

Oligodendrocyte White Matter Vulnerability
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (9)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Pre-Symptomatic Detection and Intervention Timing in Genetic
validation · proposed · Score: 0.40
Prion Strain Diversity and Selective Vulnerability in CJD
clinical · proposed · Score: 0.40
Prion Strain Diversity and Selective Vulnerability
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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