gene

PQBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PQBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

18Outgoing

9Incoming

0Experiments

0Debates

Summary

PQBP1 encodes a nuclear protein that binds polyglutamine-expanded proteins and regulates transcription. Mutations cause X-linked mental retardation; dysregulation implicated in ALS, HD, and SCAs.

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🧬 Gene Info

Gene Symbol	PQBP1
Function	encodes a small nuclear protein that specifically binds to polyglutamine (polyQ) tracts found in various disease proteins.
Subcellular Localization	Nuclear
Molecular Weight	37 kDa
Amino Acids	312 aa
Pathways	Immune Response
Ensembl ID	ENSG00000102172
GeneCards	PQBP1
Human Protein Atlas	PQBP1
N-terminal polyglutamine-binding domain	Recognizes expanded polyQ tracts
WW domain	Mediates protein-protein interactions
Nuclear localization signal (NLS)	Targets protein to the nucleus
C-terminal acidic region	Involved in transcriptional activation
Associated Diseases	Als, neurodegeneration
Interactions	AND, BRAIN INFLAMMATION, CGAS, CGAS-STING, GENES, INFLAMMATION
KG Connections	27 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PQBP1 Gene - Polyglutamine Binding Protein 1

gene · 1713 words

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Pathway Diagram

graph TD
    PQBP1["PQBP1"]
    CGAS["CGAS"]
    PQBP1 -->|"activates"| CGAS
    Inflammation{"Inflammation"}
    PQBP1 -->|"activates"| Inflammation
    Infection{"Infection"}
    PQBP1 -->|"activates"| Infection
    Als{"Als"}
    PQBP1 -->|"associated_with"| Als
    Neurodegeneration{"Neurodegeneration"}
    PQBP1 -->|"activates"| Neurodegeneration
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    PQBP1 -->|"activates"| NEURODEGENERATIVE_DISORDERS
    INFLAMMATION["INFLAMMATION"]
    PQBP1 -->|"activates"| INFLAMMATION
    BRAIN_INFLAMMATION["BRAIN INFLAMMATION"]
    PQBP1 -->|"activates"| BRAIN_INFLAMMATION
    GENES["GENES"]
    PQBP1 -->|"activates"| GENES
    STING["STING"]
    PQBP1 -->|"activates"| STING
    CGAS_STING["CGAS-STING"]
    PQBP1 -->|"activates"| CGAS_STING
    MICROGLIA["MICROGLIA"]
    PQBP1 -->|"activates"| MICROGLIA
    Immune_Response(["Immune Response"])
    PQBP1 -->|"activates"| Immune_Response
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| PQBP1
    TAU["TAU"]
    TAU -->|"activates"| PQBP1

Outgoing (18)

Target	Relation	Type	Str
CGAS	activates	gene	0.80
Infection	activates	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
CGAS-STING	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
Immune Response	activates	pathway	0.60
INFLAMMATION	activates	gene	0.60
BRAIN INFLAMMATION	activates	gene	0.60
GENES	activates	gene	0.60
STING	activates	gene	0.60
VCP	interacts_with	gene	0.60
STING	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
microglia	expressed_in	cell_type	0.60
NF-kB signaling	participates_in	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
TAU	activates	gene	0.60
CGAS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
CGAS-STING	activates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
BRAIN INFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PQBP1 in their description or question text

No additional research found