gene

PPP2R2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP2R2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

9Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for PPP2R2A — Protein Phosphatase 2 Regulatory Subunit B55 Alpha

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🧬 Gene Info

Gene Symbol	PPP2R2A
Full Name	Protein Phosphatase 2 Regulatory Subunit B55 Alpha
Chromosome	8p21.2
Function	is a hallmark of Alzheimer's disease and other neurodegenerative disorders, making it a critical therapeutic target [2](https://doi.
Molecular Weight	52 kDa
Amino Acids	447 aa
Pathways	Mapk
UniProt ID	P63151
NCBI Gene ID	5520
Ensembl ID	ENSG00000156535
OMIM	601728
GeneCards	PPP2R2A
Human Protein Atlas	PPP2R2A
Associated Diseases	neurodegeneration
Interactions	CANCER, CAV2, ERK, PIK3C3
KG Connections	13 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPP2R2A — AlphaFold P63151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP2R2A — Protein Phosphatase 2 Regulatory Subunit B55 Alpha

gene · 662 words

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Pathway Diagram

graph TD
    PPP2R2A["PPP2R2A"]
    Als{"Als"}
    PPP2R2A -->|"activates"| Als
    Aging{"Aging"}
    PPP2R2A -->|"regulates"| Aging
    Cancer{"Cancer"}
    PPP2R2A -->|"regulates"| Cancer
    CANCER["CANCER"]
    PPP2R2A -->|"regulates"| CANCER
    CAV2["CAV2"]
    PPP2R2A -->|"activates"| CAV2
    PIK3C3["PIK3C3"]
    PPP2R2A -->|"activates"| PIK3C3
    Mapk(["Mapk"])
    PPP2R2A -->|"activates"| Mapk
    neurodegeneration["neurodegeneration"]
    PPP2R2A -->|"implicated in"| neurodegeneration
    AGING["AGING"]
    AGING -->|"regulates"| PPP2R2A
    style PPP2R2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
Aging	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
CANCER	regulates	gene	0.60
Mapk	activates	pathway	0.60
CAV2	activates	gene	0.60
PIK3C3	activates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
PP2A	regulates	gene	0.60
ERK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
AGING	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP2R2A in their description or question text

No additional research found