gene

PICK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PICK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for PICK1 - Protein Interacting With C Kinase 1

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PICK1
Full Name	Protein Interacting With C Kinase 1
Aliases	Page for PICK1
Protein Family	PDZ domain proteins
Protein Type	Scaffold Protein
Function	PICK1 (Protein Interacting with C Kinase 1) is a PDZ domain-containing scaffold protein that interacts with protein kinase C (PKC) and various membrane proteins including AMPA receptors, NMDA receptor
Molecular Weight	46 kDa
Amino Acids	436 aa
UniProt ID	Q9NRF5
GeneCards	PICK1
Human Protein Atlas	PICK1
Dopamine transporter (DAT)	PICK1 interacts with DAT and influences dopamine reuptake efficiency[^8]
GLURδ2/GRID2	Involved in cerebellar synaptic plasticity[^9]
NMDA receptor subunits	Some studies suggest indirect interactions through other scaffolding proteins[^10]
Associated Diseases	neurodegeneration
Interactions	Akt, AKT1, CHRNA7, JAK2
KG Connections	14 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PICK1 — AlphaFold Q9NRF5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PICK1 - Protein Interacting With C Kinase 1

gene · 3315 words

→

PICK1 Protein

protein · 640 words

→

Pathway Diagram

graph TD
    PICK1["PICK1"]
    PICK1 -->|"interacts"| Als["Als"]
    PICK1 -->|"interacts"| ALS["ALS"]
    PICK1 -->|"interacts"| JAK2["JAK2"]
    PICK1 -->|"interacts"| AKT1["AKT1"]
    PICK1 -->|"interacts"| CHRNA7["CHRNA7"]
    PICK1 -->|"interacts"| Neurogenesis["Neurogenesis"]
    PICK1 -->|"interacts"| Neuron["Neuron"]
    PICK1 -->|"interacts"| AND["AND"]
    AKT1 -->|"interacts"| PICK1
    CHRNA7 -->|"interacts"| PICK1
    JAK2 -->|"interacts"| PICK1

Outgoing (10)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Akt	interacts_with	protein	0.60
JAK2	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CHRNA7	interacts_with	gene	0.60
Neurogenesis	interacts_with	pathway	0.60
Neuron	interacts_with	cell_type	0.60
Neuron	expressed_in	cell_type	0.55
disease	interacts_with	disease	0.50

Incoming (4)

Source	Relation	Type	Str
APP	regulates	gene	0.60
AKT1	interacts_with	gene	0.60
CHRNA7	interacts_with	gene	0.60
JAK2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PICK1 in their description or question text

No additional research found