| Gene Symbol | PEX5 |
| Full Name | Peroxisome Biogenesis Factor 5 |
| Aliases | Page for PEX5 Gene, Page for PEX5 Protein |
| Chromosome | 12p13.3 |
| Function | Cargo Recognition: PEX5 binds PTS1-containing proteins (SKL motif) in the cytosol |
| Molecular Weight | 131 kDa |
| Amino Acids | 631 aa |
| UniProt ID | P50571 |
| NCBI Gene ID | 5835 |
| Ensembl ID | ENSG00000120799 |
| GeneCards | PEX5 |
| Human Protein Atlas | PEX5 |
| N-terminal domain (NTD) | Approximately 300 residues, contains the binding sites for PEX7 (the PTS2 receptor) and the PEX1-PEX6 AAA-ATPase complex. This region is involved in receptor recycling. |
| TPR domain | The C-terminal portion contains tetratricopeptide repeat (TPR) motifs that form a superhelical structure responsible for recognizing the PTS1 cargo. |
| Cargo-binding pocket | A hydrophobic pocket that accommodates the PTS1 motif and related sequences. |
| Associated Diseases | multiple sclerosis |
| Interactions | ATM, GSK3, PEX3, PPAR |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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