protein

P62PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P62PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

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Summary

P62 Protein (Sequestosome 1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	P62PROTEIN
Protein Type	Adaptor Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	ALS, FTD
Molecular Weight	62 kDa
GeneCards	P62PROTEIN
Human Protein Atlas	P62PROTEIN
PB1 Domain	N-terminal Phox and Bem1p domain for oligomerization
ZZ Domain	Zinc finger domain for protein interactions
TBI (TBK1 Interaction) Domain	Phosphorylated by TBK1 and mTORC1
LIR (LC3-Interacting Region)	Binds LC3/GABARAP proteins on autophagosomes
UBA Domain (Ubiquitin-Associated)	Binds polyubiquitin chains for selective autophagy
Signaling Hub	Integrates signals from multiple pathways (mTOR, Nrf2, NF-κB)
Protein Quality Control	Targets misfolded proteins for autophagic degradation
Cell Survival	Nrf2-mediated antioxidant responses
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	6-OHDA, ABCA1, ABCD3, ABCG1, ACHE, ACOD1
KG Connections	2886 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

p62 Protein (Sequestosome-1)

protein · 920 words

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Pathway Diagram

graph TD
    P62PROTEIN["P62PROTEIN"]
    neurodegeneration["neurodegeneration"]
    P62PROTEIN -->|"implicated_in"| neurodegeneration
    style P62PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P62PROTEIN in their description or question text

No additional research found