| Gene Symbol | P62PROTEIN |
| Protein Type | Adaptor Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | ALS, FTD |
| Molecular Weight | 62 kDa |
| GeneCards | P62PROTEIN |
| Human Protein Atlas | P62PROTEIN |
| PB1 Domain | N-terminal Phox and Bem1p domain for oligomerization |
| ZZ Domain | Zinc finger domain for protein interactions |
| TBI (TBK1 Interaction) Domain | Phosphorylated by TBK1 and mTORC1 |
| LIR (LC3-Interacting Region) | Binds LC3/GABARAP proteins on autophagosomes |
| UBA Domain (Ubiquitin-Associated) | Binds polyubiquitin chains for selective autophagy |
| Signaling Hub | Integrates signals from multiple pathways (mTOR, Nrf2, NF-κB) |
| Protein Quality Control | Targets misfolded proteins for autophagic degradation |
| Cell Survival | Nrf2-mediated antioxidant responses |
| Associated Diseases | Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN |
| Interactions | 6-OHDA, ABCA1, ABCD3, ABCG1, ACHE, ACOD1 |
| KG Connections | 2886 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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