| Gene Symbol | COPB2 |
| Full Name | Coatomer Protein Complex Subunit Beta 2 |
| Chromosome | 3q29 |
| Protein Family | Coatomer complex (COPI) |
| Function | encodes the beta prime subunit of the COPI (Coat Protein Complex I) coatomer complex |
| UniProt ID | P49407 |
| NCBI Gene ID | 9276 |
| Ensembl ID | ENSG00000185103 |
| OMIM | 607488 |
| GeneCards | COPB2 |
| Human Protein Atlas | COPB2 |
| Cargo recognition | COPB2 recognizes dilysine (KKXX) motifs in the cytoplasmic tails of transmembrane proteins |
| Vesicle formation | The coat polymerizes around the Golgi membrane to drive vesicle budding |
| Cargo sorting | Selectively incorporates cargo molecules into forming vesicles |
| Membrane deformation | Coordinates membrane curvature for vesicle formation |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Hereditary Spastic Paraplegia, Lysosomal Storage Disorders |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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