protein

LKB1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LKB1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

LKB1 phosphorylates and activates the AMP-activated protein kinase (AMPK) and 12 other related kinases, forming the AMPK family.

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🔬 Protein Info

Gene Symbol	LKB1PROTEIN
Full Name	lkb1-protein
Protein Type	Protein
Function	is a serine/threonine protein kinase that functions as the master regulator of cellular energy metabolism, stress response, and cell polarity.
Subcellular Localization	signals: Two NLS sequences - Scaffolding protein interaction sites** ###
Molecular Weight	48 kDa
UniProt ID	Search UniProt
GeneCards	LKB1PROTEIN
Human Protein Atlas	LKB1PROTEIN
N-lobe	Contains the glycine-rich GxGxxGXV motif (residues 30-37) for ATP binding
C-lobe	Contains the catalytic Asp-Phe-Gly motif
Activation loop	Contains Ser-431, the regulatory auto-phosphorylation site
Ste20-like kinase unique insertion	Distinguishes LKB1 from conventional protein kinases
Dimerization interface	Mediates homodimer formation
Nuclear localization signals	Two NLS sequences
Associated Diseases	multiple sclerosis
Known Drugs/Compounds	metformin, rapamycin
Interactions	ACETYL-COA, ACLY, ACTB, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	141 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LKB1PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

lkb1-protein

protein · 1326 words

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Pathway Diagram

graph TD
    LKB1PROTEIN["LKB1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    LKB1PROTEIN -->|"implicated_in"| neurodegeneration
    style LKB1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning LKB1PROTEIN in their description or question text

No additional research found