| Gene Symbol | LKB1PROTEIN |
| Full Name | lkb1-protein |
| Protein Type | Protein |
| Function | is a serine/threonine protein kinase that functions as the master regulator of cellular energy metabolism, stress response, and cell polarity. |
| Subcellular Localization | signals**: Two NLS sequences - **Scaffolding protein interaction sites** ### |
| Molecular Weight | 48 kDa |
| UniProt ID | Search UniProt |
| GeneCards | LKB1PROTEIN |
| Human Protein Atlas | LKB1PROTEIN |
| N-lobe | Contains the glycine-rich GxGxxGXV motif (residues 30-37) for ATP binding |
| C-lobe | Contains the catalytic Asp-Phe-Gly motif |
| Activation loop | Contains Ser-431, the regulatory auto-phosphorylation site |
| Ste20-like kinase unique insertion | Distinguishes LKB1 from conventional protein kinases |
| Dimerization interface | Mediates homodimer formation |
| Nuclear localization signals | Two NLS sequences |
| Associated Diseases | multiple sclerosis |
| Known Drugs/Compounds | metformin, rapamycin |
| Interactions | ACETYL-COA, ACLY, ACTB, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER DISEASE |
| KG Connections | 141 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!