gene

DLX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections
0Hypotheses
1Analyses
7Outgoing
1Incoming
0Experiments
1Debates

Summary

DLX1 Gene

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🧬 Gene Info
Gene SymbolDLX1
Chromosome2q31.1
Protein TypeGene
FunctionDLX1 (Distal-Less Homeobox 1) encodes a homeobox transcription factor essential for embryonic development of the forebrain and craniofacial structures.
Primary Expressiondeveloping GABAergic interneurons of the basal ganglia, cortex, and hippocampus, where it promo
Pathwaysoxidative stress response
GeneCardsDLX1
Human Protein AtlasDLX1
Associated Diseasesneurodegeneration
InteractionsIL1B, TNFA
KG Connections8 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DLX1 Gene

gene · 624 words

Pathway Diagram

graph TD
    DLX1["DLX1"]
    style DLX1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    IL1B["IL1B"]
    TNFA["TNFA"]
    neuroinflammation["neuroinflammation"]
    oxidative_stress_response(("oxidative stress response"))
    microglia["microglia"]
    neurons["neurons"]
    LHX6["LHX6"]
    neurodegeneration["neurodegeneration"]

    DLX1 -->|"activates"| IL1B
    DLX1 -->|"activates"| TNFA
    DLX1 -->|"activates"| neuroinflammation
    DLX1 -->|"participates_in"| oxidative_stress_response
    DLX1 -->|"expressed_in"| microglia
    DLX1 -->|"expressed_in"| neurons
    DLX1 -->|"associated_with"| LHX6
    DLX1 -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class IL1B gene
    class TNFA gene
    class neuroinflammation protein
    class oxidative_stress_response pathway
    class microglia mechanism
    class neurons mechanism
    class LHX6 gene
    class neurodegeneration disease

Outgoing (7)

TargetRelationTypeStr
IL1Bactivatesgene0.55
TNFAactivatesgene0.55
neuroinflammationactivatesdisease0.55
LHX6associated_withgene0.55
oxidative stress responseparticipates_inpathway0.55

Incoming (1)

SourceRelationTypeStr
h-0bdc3803targetshypothesis0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.726

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD trans

closed · Rounds: 4 · Score: 0.95 · 2026-04-03