| Gene Symbol | KCNK14 |
| Aliases | KCNK14PROTEIN |
| Subcellular Localization | </strong></td><td>Plasma membrane</td></tr> |
| Molecular Weight | 45 kDa |
| GeneCards | KCNK14 |
| Human Protein Atlas | KCNK14 |
| Four transmembrane segments | Two pore-forming domains (P1 and P2) that create the ion conduction pathway |
| Two selectivity filters | The channel passes potassium ions with high selectivity |
| Extracellular loops | Form the channel entrance and contribute to ion selectivity |
| Cytoplasmic N- and C-termini | Contain regulatory domains that modulate channel activity |
| pH sensitivity | Intracellular pH modulates channel activity through protonation sites |
| Volatile anesthetics | Activated by halogenated anesthetics, contributing to sedation |
| Hypoxia | Oxygen levels directly affect channel function, linking metabolism to excitability |
| Mechanical stretch | Exhibits mechanosensitivity similar to baroreceptor neurons |
| Neuronal hyperexcitability | Reduced KCNK14 activity may contribute to network hyperactivity observed in early AD |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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