| Gene Symbol | KCNK12 |
| Aliases | KCNK12PROTEIN |
| Subcellular Localization | </strong></td><td>Plasma membrane</td></tr> |
| Molecular Weight | 38 kDa |
| GeneCards | KCNK12 |
| Human Protein Atlas | KCNK12 |
| Four transmembrane segments | Two pore-forming domains (P1 and P2) create the ion conduction pathway |
| Two selectivity filters | Potassium-selective pores allow K+ passage |
| Extracellular loops | Form the channel entrance and determine ion selectivity |
| Cytoplasmic termini | Contain regulatory domains that modulate channel activity |
| Halothane sensitivity | Activated by volatile anesthetics through specific binding sites |
| Hypoxia responses | Oxygen levels directly modulate channel activity |
| pH sensitivity | Both intracellular and extracellular pH affect channel gating |
| Lipid modulation | Phospholipids and fatty acids regulate channel activity |
| Neuronal excitability | Altered KCNK12 affects resting membrane potential and excitability |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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