gene

KCNJ10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNJ10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

18Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for KCNJ10 Gene

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🧬 Gene Info

Gene Symbol	KCNJ10
Full Name	Potassium Inwardly Rectifying Channel Subfamily J Member 10 (Kir4.1)
Chromosome	1q22
Protein Type	Channel
Function	Kir4.1 channels serve multiple critical functions in the nervous system:
Primary Expression	glial cells—astrocytes and oligodendrocytes—where it plays essential roles in potassium homeostasis, extracellular potassium clearance, and maintainin
Subcellular Localization	</strong></td><td>Plasma membrane (astrocyte perivascular endfeet, oligodendrocyte processes)</td></tr>
Amino Acids	379 aa
Exons	4
Pathways	oxidative stress response, synaptic plasticity, unfolded protein response
UniProt ID	[P48169](https://www.uniprot.org/uniprot/P48169)
Ensembl ID	ENSG00000177853
GeneCards	KCNJ10
Human Protein Atlas	KCNJ10
N-terminus (1-50 aa)	Cytoplasmic domain containing the cytoplasmic domain that forms the channel gate
Associated Diseases	neurodegeneration
Interactions	ALS, ALZHEIMER, APP/PS1, ASTROCYTES, HUNTINGTON, NRF2
KG Connections	22 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Kir4.1 Potassium Channel (KCNJ10)

protein · 1695 words

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KCNJ10 Gene

gene · 1433 words

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Pathway Diagram

flowchart TD
    N0["KCNJ10"]
    N1["Alzheimer"]
    N0 -->|"activates"| N1
    N2["Huntington"]
    N0 -->|"activates"| N2
    N3["Als"]
    N0 -->|"activates"| N3
    N4["Amyotrophic Lateral Sclerosis"]
    N0 -->|"activates"| N4
    N5["Neurodegeneration"]
    N0 -->|"activates"| N5
    N6["APP/PS1"]
    N0 -->|"activates"| N6
    N7["ASTROCYTES"]
    N0 -->|"activates"| N7
    N8["SLC1A3"]
    N0 -->|"activates"| N8
    N9["Neuron"]
    N0 -->|"activates"| N9
    N10["Astrocyte"]
    N0 -->|"activates"| N10
    N11["ALS"]
    N0 -->|"activates"| N11
    N12["HUNTINGTON"]
    N0 -->|"activates"| N12
    N13["Sod1"]
    N0 -->|"activates"| N13
    N12 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 disease
    class N6 gene
    class N7 gene
    class N8 gene
    class N11 gene
    class N12 gene
    class N13 protein

Outgoing (18)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Huntington	activates	disease	0.65
Als	activates	disease	0.65
APP/PS1	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
Neuron	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
ALS	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
Sod1	activates	protein	0.60
SLC1A3	activates	gene	0.60
unfolded protein response	participates_in	pathway	0.55
oxidative stress response	participates_in	pathway	0.55
synaptic plasticity	participates_in	pathway	0.55
NRF2	activates	gene	0.55
SLC1A2	activates	gene	0.55

Incoming (4)

Source	Relation	Type	Str
HUNTINGTON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ALS	activates	gene	0.60
SLC1A3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNJ10 in their description or question text

No additional research found