| Gene Symbol | KCNJ10 |
| Full Name | Potassium Inwardly Rectifying Channel Subfamily J Member 10 (Kir4.1) |
| Chromosome | 1q22 |
| Protein Type | Channel |
| Function | Kir4.1 channels serve multiple critical functions in the nervous system: |
| Primary Expression | glial cells—astrocytes and oligodendrocytes—where it plays essential roles in potassium homeostasis, extracellular potassium clearance, and maintainin |
| Subcellular Localization | </strong></td><td>Plasma membrane (astrocyte perivascular endfeet, oligodendrocyte processes)</td></tr> |
| Amino Acids | 379 aa |
| Exons | 4 |
| Pathways | oxidative stress response, synaptic plasticity, unfolded protein response |
| UniProt ID | [P48169](https://www.uniprot.org/uniprot/P48169) |
| Ensembl ID | ENSG00000177853 |
| GeneCards | KCNJ10 |
| Human Protein Atlas | KCNJ10 |
| N-terminus (1-50 aa) | Cytoplasmic domain containing the cytoplasmic domain that forms the channel gate |
| Associated Diseases | neurodegeneration |
| Interactions | ALS, ALZHEIMER, APP/PS1, ASTROCYTES, HUNTINGTON, NRF2 |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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