concept

IMMUNE EVASION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IMMUNE EVASION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

1Analyses

1Outgoing

20Incoming

0Experiments

2Debates

No summary available yet.

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💡 Concept Info

Name	IMMUNE EVASION
Key Genes/Proteins	ERK
Related Diseases	AUTOPHAGY

Pathway Diagram

graph TD
    IMMUNE_EVASION["IMMUNE EVASION"]
    IMMUNE_EVASION -->|"contributes to"| Therapy_Resistance["Therapy Resistance"]
    NPM1["NPM1"] -->|"promotes"| IMMUNE_EVASION
    G3BP1["G3BP1"] -->|"promotes"| IMMUNE_EVASION
    Tumor_Associated_Macrophages["Tumor-Associated Macrophages"] -->|"mediates"| IMMUNE_EVASION
    Myeloid_Derived_Suppressor_Cel["Myeloid-Derived Suppressor Cells"] -->|"mediates"| IMMUNE_EVASION
    Regulatory_T_Cells["Regulatory T Cells"] -->|"mediates"| IMMUNE_EVASION
    Autophagy["Autophagy"] -->|"modulates"| IMMUNE_EVASION
    VDAC2["VDAC2"] -->|"inhibits"| IMMUNE_EVASION
    Tumor_Heterogeneity["Tumor Heterogeneity"] -->|"contributes to"| IMMUNE_EVASION

Outgoing (1)

Target	Relation	Type	Str
Therapy Resistance	contributes_to	phenotype	0.85

Incoming (20)

Source	Relation	Type	Str
NPM1	associated_with	protein	0.95
G3BP1	promotes	protein	0.94
Myeloid-Derived Suppressor Cells	mediates	cell_type	0.90
Regulatory T Cells	mediates	cell_type	0.90
Extracellular Matrix Stiffness	associated_with	mechanism	0.90
Piezo1	promotes	protein	0.90
Tumor-Associated Macrophages	mediates	cell_type	0.90
Autophagy	modulates	process	0.85
Tumour Neo-Innervation	regulates	process	0.85
VDAC2	inhibits	gene	0.82
AUTOPHAGY	promotes	process	0.80
Tumor Heterogeneity	contributes_to	phenotype	0.80
MYC	associated_with	gene	0.80
NF-KB Pathway	associated_with	pathway	0.80
Extracellular Matrix	associated_with	structure	0.80
ECM stiffness	promotes	phenotype	0.80
ALK inhibitors	associated_with	drug	0.70
AUTOPHAGY	involved_in	process	0.70
AUTOPHAGY	regulates	phenotype	0.65
ERK	causes	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.445

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 1.00 · 2026-04-19

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning IMMUNE EVASION in their description or question text

No additional research found