concept

HDAC INHIBITORS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC INHIBITORS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

3Analyses

46Outgoing

2Incoming

0Experiments

3Debates

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💡 Concept Info

Name	HDAC INHIBITORS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HDAC Inhibitors

therapeutics · 619 words

→

Pathway Diagram

graph TD
    HDAC_INHIBITORS["HDAC INHIBITORS"]
    HDAC_INHIBITORS -->|"inhibits"| HDAC["HDAC"]
    HDAC_INHIBITORS -->|"modulates"| Histone_Acetylation["Histone Acetylation"]
    HDAC_INHIBITORS -->|"upregulates"| ATP2A3["ATP2A3"]
    HDAC_INHIBITORS -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
    HDAC_INHIBITORS -->|"inhibits"| Amyloid_Beta_Plaque_Formation["Amyloid Beta Plaque Formation"]
    HDAC_INHIBITORS -->|"treats"| Neurological_Diseases["Neurological Diseases"]
    HDAC_INHIBITORS -->|"modulates"| Chromatin_Remodeling["Chromatin Remodeling"]
    HDAC_INHIBITORS -->|"inhibits"| Tau_Protein_Phosphorylation["Tau Protein Phosphorylation"]

Outgoing (46)

Target	Relation	Type	Str
healthy aging	associated_with	phenotype	0.90
learning consolidation in neurodegeneration	associated_with	phenotype	0.90
Amyloid Beta	associated_with	protein	0.90
Alzheimer'S Disease	treats	disease	0.90
Histone Acetylation	modulates	process	0.90
Neurological Diseases	treats	disease	0.88
ATP2A3	upregulates	gene	0.88
Cognitive Impairment	associated_with	phenotype	0.85
Metabolic Homeostasis	associated_with	process	0.85
MAPT	downregulates	protein	0.85
Alzheimer's Disease	treats	disease	0.85
Amyloid Beta	inhibits	protein	0.85
Neuroinflammation	inhibits	process	0.85
TAU	downregulates	protein	0.85
Chromatin Remodeling	modulates	process	0.85
Cell Survival	promotes	process	0.85
Microtubule Stability	promotes	phenotype	0.85
Neurological Diseases	treats	disease	0.85
Amyloid Beta Plaque Formation	inhibits	process	0.85
Tau Protein Phosphorylation	inhibits	process	0.80
Microtubule Stability	associated_with	process	0.80
Endometrial Carcinoma	treats	disease	0.80
Osteosarcoma	treats	disease	0.80
Multiple Myeloma	treats	disease	0.80
Transcriptional Repression	modulates	process	0.80
Cell Survival	associated_with	process	0.80
Synaptic failure	treats	process	0.80
Neuroinflammation	inhibits	process	0.80
Neurodegenerative Diseases	treats	disease	0.80
Gene Expression	upregulates	process	0.80
Alzheimer's disease	therapeutic_for	disease	0.80
Isoform Selectivity	modulates	mechanism	0.80
Learning and Memory Impairment	treats	phenotype	0.80
Glioma	treats	disease	0.80
EPIGENOME	restores	process	0.80
Ovarian Cancer	treats	disease	0.80
ALZHEIMER'S DISEASE	treats	disease	0.75
Microtubule Stability	upregulates	process	0.75
Cell Survival	upregulates	process	0.75
microglial_EV_cargo_reprogramming	causes	phenotype	0.70
Blood-Brain Barrier Penetration	modulates	process	0.70
Blood-Brain Barrier Penetration	associated_with	mechanism	0.70
Nervous System Diseases	treats	disease	0.70
MERTK	activates	gene	0.50
HDAC	references	gene	0.40
SIRT1	references	gene	0.40

Incoming (2)

Source	Relation	Type	Str
HDAC	therapeutic_target	protein	0.95
Blood-Brain Barrier Penetration	associated_with	phenotype	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-02 | 0 hypotheses

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

While the study shows HDAC1/2 deletion improves amyloid clearance and cognition,

closed · Rounds: 4 · Score: 0.95 · 2026-04-13

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-02

Extracellular vesicle biomarkers for early AD detection

closed · Rounds: 4 · Score: 0.87 · 2026-04-02

Related Research

Hypotheses and analyses mentioning HDAC INHIBITORS in their description or question text

No additional research found