concept

GLUTAMATE EXCITOTOXICITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUTAMATE EXCITOTOXICITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

2Analyses

18Outgoing

17Incoming

0Experiments

2Debates

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💡 Concept Info

Name	GLUTAMATE EXCITOTOXICITY
Key Genes/Proteins	BDNF, SLC7A11, STING, TET2
Related Diseases	GLUTAMATE, Tau Secretion
Related Pathways	NLRP3 INFLAMMASOME

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Glutamate Excitotoxicity in Neurodegeneration

mechanism · 2206 words

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Pathway Diagram

graph TD
    GLUTAMATE_EXCITOTOXICITY[GLUTAMATE EXCITOTOXICITY]
    GLUTAMATE_EXCITOTOXICITY -->|activates| STING[STING]
    GLUTAMATE_EXCITOTOXICITY -->|contributes to| Amyotrophic_Lateral_Sclerosis[Amyotrophic Lateral Sclerosis]
    GLUTAMATE_EXCITOTOXICITY -->|involved_in| PARKINSON_S_DISEASE[PARKINSON'S DISEASE]
    GLUTAMATE_EXCITOTOXICITY -->|involved_in| ALZHEIMER_S_DISEASE[ALZHEIMER'S DISEASE]
    GLUTAMATE_EXCITOTOXICITY -->|involved_in| ALS[ALS]
    GLUTAMATE_EXCITOTOXICITY -->|contributes to| Neurodegeneration[Neurodegeneration]
    GLUTAMATE_EXCITOTOXICITY -->|causes| neuronal_cell_death[neuronal cell death]
    SLC7A11[SLC7A11] -->|involved_in| GLUTAMATE_EXCITOTOXICITY
    Corticosterone[Corticosterone] -->|mediates| GLUTAMATE_EXCITOTOXICITY
    GR[GR] -->|contributes to| GLUTAMATE_EXCITOTOXICITY
    TET2[TET2] -->|treats| GLUTAMATE_EXCITOTOXICITY
    BDNF[BDNF] -.protects against.-> GLUTAMATE_EXCITOTOXICITY
    A_[Aβ] -->|activates| GLUTAMATE_EXCITOTOXICITY
    GLUTAMATE[GLUTAMATE] -->|causes| GLUTAMATE_EXCITOTOXICITY
    ASTROCYTES[ASTROCYTES] -.protects against.-> GLUTAMATE_EXCITOTOXICITY

Outgoing (18)

Target	Relation	Type	Str
Synapse damage	causes	phenotype	0.90
Amyotrophic Lateral Sclerosis	causes	disease	0.90
STING	activates	protein	0.90
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.90
PARKINSON'S DISEASE	involved_in	disease	0.90
ALZHEIMER'S DISEASE	involved_in	disease	0.90
ALS	involved_in	disease	0.90
STING	activates	protein	0.85
Neurodegeneration	contributes_to	process	0.80
Tau Secretion	enhances	phenotype	0.70
neuronal cell death	causes	process	0.70
NLRP3 INFLAMMASOME	associated_with	pathway	0.50
GALANTAMINE	associated_with	drug	0.45
RIVASTIGMINE	associated_with	drug	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
DONEPEZIL	associated_with	drug	0.45
MEMANTINE	associated_with	drug	0.45
SPINAL CORD	associated_with	brain_region	0.45

Incoming (17)

Source	Relation	Type	Str
ALS	associated_with	disease	0.90
SLC7A11	involved_in	gene	0.80
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.80
Corticosterone	mediates	compound	0.80
GR	contributes_to	receptor	0.75
Aβ	activates	protein	0.70
TET2	treats	gene	0.70
BDNF	protects_against	gene	0.70
GLUTAMATE	causes	phenotype	0.70
GLUTAMATE	inhibits	phenotype	0.70
ASTROCYTES	protects_against	cell_type	0.70
HIPPOCAMPUS	causes	brain_region	0.65
HIPPOCAMPUS	activates	brain_region	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
SLC7A11	regulates	gene	0.65
STING	causes	gene	0.65
33434745	potentiates	paper	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

neuroscience | 2026-04-28 | 7 hypotheses Top: 0.808

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Structured research brief for hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thala

active · Rounds: 4 · Score: 0.82 · 2026-04-28

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning GLUTAMATE EXCITOTOXICITY in their description or question text

No additional research found