gene

SURF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SURF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

3Outgoing

2Incoming

0Experiments

0Debates

Summary

Gene profile: SURF4

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🧬 Gene Info

Gene Symbol	SURF4
Full Name	SURF4 Homolog
Chromosome	8q11.23
Protein Type	ER Cargo Receptor
Function	is a highly conserved gene encoding an endoplasmic reticulum (ER) cargo receptor protein that plays a critical role in the early secretory pathway.
Amino Acids	440 aa
NCBI Gene ID	6836
OMIM	605332
GeneCards	SURF4
Human Protein Atlas	SURF4
Cargo Recognition	SURF4 binds to properly folded secretory proteins and specific transmembrane cargo molecules, serving as a physical link between cargo and the COPII coat 3.
Export Site Formation	SURF4 localizes to ER exit sites (ERES) where it helps nucleate the formation of COPII vesicles. Its cytoplasmic tail directly engages Sec24 through the DxE motif, recruiting the coat machinery 6.
Associated Diseases	Cardiovascular
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SURF4 — SURF4 Homolog

gene · 2988 words

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Pathway Diagram

flowchart TD
    SURF4(["SURF4"])
    Cardiovascular["Cardiovascular"]
    Cholesterol["Cholesterol"]
    Lipid_Metabolism["Lipid Metabolism"]
    GENES(["GENES"])
    GPR146(["GPR146"])
    neurodegeneration["neurodegeneration"]

    SURF4 -->|"implicated in"| Cardiovascular
    SURF4 -->|"implicated in"| Cholesterol
    SURF4 -->|"implicated in"| Lipid_Metabolism
    GENES -->|"implicated in"| SURF4
    GPR146 -->|"implicated in"| SURF4
    SURF4 -->|"implicated in"| neurodegeneration

    style SURF4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
Cardiovascular	implicated_in	disease	0.65
Cholesterol	implicated_in	pathway	0.60
Lipid Metabolism	implicated_in	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
GPR146	implicated_in	gene	0.60
GENES	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SURF4 in their description or question text

No additional research found