gene

CAPRIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAPRIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

1Hypotheses

0Analyses

9Outgoing

0Incoming

0Experiments

0Debates

Summary

CAPRIN1 encodes a RNA-binding protein critical for stress granule formation, mRNA transport, and translational control. CAPRIN1 is implicated in ALS, FTD, and potentially Alzheimer's disease through its role in RNA metabolism and protein aggregation.

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🧬 Gene Info

Gene Symbol	CAPRIN1
Full Name	Cell Cycle Associated Protein 1
Chromosome	11p13
Function	encodes an RNA-binding protein that plays critical roles in stress granule formation, mRNA transport, and translational regulation.
Primary Expression	various brain regions:
Molecular Weight	78 kDa
Amino Acids	709 aa
Exons	17
Pathways	Synaptic Plasticity
UniProt ID	Q14444
NCBI Gene ID	9908
Ensembl ID	ENSG00000135387
OMIM	608157
GeneCards	CAPRIN1
Human Protein Atlas	CAPRIN1
Associated Diseases	Autism
Interactions	G3BP2
KG Connections	9 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CAPRIN1 — AlphaFold Q14444 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CAPRIN1 Gene

gene · 1472 words

→

CAPRIN1 Protein

protein · 1350 words

→

Pathway Diagram

graph TD
    CAPRIN1["CAPRIN1"]
    Als{"Als"}
    CAPRIN1 -->|"interacts with"| Als
    CAPRIN1 -->|"activates"| Als
    Autism{"Autism"}
    CAPRIN1 -->|"associated with"| Autism
    Ms{"Ms"}
    CAPRIN1 -->|"activates"| Ms
    G3BP2["G3BP2"]
    CAPRIN1 -->|"interacts with"| G3BP2
    G3BP1["G3BP1"]
    CAPRIN1 -->|"protects against"| G3BP1
    Oxidative_Stress(["Oxidative Stress"])
    CAPRIN1 -->|"activates"| Oxidative_Stress
    Synaptic_Plasticity(["Synaptic Plasticity"])
    CAPRIN1 -->|"regulates"| Synaptic_Plasticity
    neurodegeneration["neurodegeneration"]
    CAPRIN1 -->|"implicated in"| neurodegeneration
    style CAPRIN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Autism	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	interacts_with	disease	0.65
Als	activates	disease	0.65
Synaptic Plasticity	regulates	pathway	0.60
G3BP1	protects_against	gene	0.60
Oxidative Stress	activates	pathway	0.60
G3BP2	interacts_with	gene	0.60
synaptic plasticity	participates_in	pathway	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Competition with G3BP1-Caprin1/FMRP Scaffold Formation	0.590	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CAPRIN1 in their description or question text

No additional research found