gene 961 words KG: G3BP2
Contents

G3BP2 - Ras-GTPase-Activating Protein-Binding Protein 2

🧬 Gene Info
Gene SymbolG3BP2
Full NameRas-GTPase-Activating Protein-Binding Protein 2
AliasesPage for G3BP2, Page for G3BP2 Protein
Chromosome4p16.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight56 kDa
Amino Acids523 aa
PathwaysNF-κB, MAPK
UniProt ID[Q9UWR1](https://www.uniprot.org/uniprot/Q9UWR1)
Ensembl IDENSG00000138798
GeneCardsG3BP2
Human Protein AtlasG3BP2
RRM Domains (RNA Recognition Motifs)Two RRM domains (RRM1 and RRM2) for RNA binding
RG-rich RegionArginine-glycine rich region for protein-protein interactions
NTF2-like DomainMediates homodimerization and stress granule targeting
Associated DiseasesAls, Cancer
InteractionsCAPRIN1, G3BP1, Proteasome, RNA, TDP-43
KG Connections38 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (11)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Cross-Seeding Prevention Strategy
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (2)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (8)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: expressed_in
Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: expressed_in
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: interacts_with
Proteasome-Ubiquitin System Dysfunction Validation in P
experiment · KG edge: activates

Knowledge Graph (12 edges)

G3BP2 activates G3BP1
CAPRIN1 interacts_with G3BP2
G3BP2 inhibits G3BP1
G3BP2 associated_with G3BP1
G3BP2 interacts_with G3BP1
G3BP2 expressed_in Brainstem
G3BP1 activates G3BP2
G3BP1 regulates G3BP2
G3BP2 regulates TDP-43
G3BP1 inhibits G3BP2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)