DDX6

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

DEAD-Box Helicase 6 - RNA helicase involved in stress granules, P-bodies, and ALS/FTD pathogenesis

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flowchart TD
    N0["DDX6"]
    N1["Als"]
    N0 -->|"interacts with"| N1
    N2["Inflammation"]
    N0 -->|"activates"| N2
    N3["UBIQUITIN"]
    N0 -->|"interacts with"| N3
    N4["Autophagy"]
    N0 -->|"activates"| N4
    N5["Inflammasome"]
    N0 -->|"activates"| N5
    N6["Er Stress"]
    N0 -->|"activates"| N6
    N7["AUTOPHAGY"]
    N0 -->|"activates"| N7
    N8["NLRP3"]
    N0 -->|"activates"| N8
    N9["AND"]
    N0 -->|"activates"| N9
    N10["P62"]
    N0 -->|"activates"| N10
    N11["ASC"]
    N0 -->|"activates"| N11
    N7 -->|"activates"| N0
    N11 -->|"activates"| N0
    N8 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 pathway
    class N5 pathway
    class N6 pathway
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene
    class N11 gene

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