gene

VAMP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

9Outgoing

5Incoming

0Experiments

0Debates

Summary

VAMP3 (Cellubrevin) - SNARE protein essential for synaptic vesicle trafficking, endosomal recycling, and neurotransmitter release in the central nervous system

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🧬 Gene Info

Gene Symbol	VAMP3
Full Name	Vesicle Associated Membrane Protein 3
Aliases	Cellubrevin
Chromosome	1p36.22
Function	is a small membrane protein with a simple structural organization
Primary Expression	neurons, neuroendocrine cells, and various non-neuronal tissues, where it participates in diverse trafficking pathways including synaptic vesicle exoc
Molecular Weight	12 kDa
Amino Acids	116 aa
Exons	6
UniProt ID	Q15886
NCBI Gene ID	9515
Ensembl ID	ENSG00000143842
OMIM	606280
GeneCards	VAMP3
Human Protein Atlas	VAMP3
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VAMP3 — AlphaFold Q15886 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VAMP3 Gene

gene · 1682 words

→

VAMP3 Protein (Cellubrevin)

protein · 1104 words

→

Pathway Diagram

flowchart TD
    N0["VAMP3"]
    N1["Als"]
    N0 -->|"contributes to"| N1
    N2["ALS"]
    N0 -->|"contributes to"| N2
    N3["SGMS1"]
    N0 -->|"associated with"| N3
    N4["Stem Cell"]
    N0 -->|"contributes to"| N4
    N5["Neuron"]
    N0 -->|"contributes to"| N5
    N6["AND"]
    N0 -->|"associated with"| N6
    N7["GENES"]
    N0 -->|"associated with"| N7
    N8["Rb"]
    N0 -->|"associated with"| N8
    N3 -->|"associated with"| N0
    N0 -->|"expressed in"| N4
    N0 -->|"expressed in"| N5
    N9["Genes"]
    N0 -->|"associated with"| N9
    N10["DUSP2"]
    N10 -->|"co discussed"| N0
    N7 -->|"regulates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N6 gene
    class N7 gene
    class N8 protein
    class N10 gene

Outgoing (9)

Target	Relation	Type	Str
ALS	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Stem Cell	contributes_to	cell_type	0.60
Neuron	contributes_to	cell_type	0.60
GENES	associated_with	gene	0.60
SGMS1	associated_with	gene	0.60
Rb	associated_with	protein	0.60
Stem Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
SGMS1	associated_with	gene	0.60
DUSP2	co_discussed	gene	0.50
GENES	regulates	gene	0.50
NEURON	co_discussed	gene	0.50
microcephaly	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VAMP3 in their description or question text

No additional research found