| Gene Symbol | Chloride Voltage-Gated Channel 1 |
| Chromosome | 7q34 |
| Protein Type | Channel |
| Function | CLC-1 is a homodimeric voltage-gated chloride channel belonging to the CLC chloride channel family. |
| Primary Expression | Skeletal muscle (type I and type II fibers) |
| Amino Acids | 994 aa |
| Pathways | insulin signaling |
| UniProt ID | P35523 |
| NCBI Gene ID | 1187 |
| Ensembl ID | ENSG00000100137 |
| OMIM | 118425 |
| Muscle excitability | Maintains the resting membrane potential in skeletal muscle fibers |
| Chloride conductance | Provides the majority of resting conductance in muscle |
| Repolarization | Helps terminate muscle action potentials |
| Volume regulation | Contributes to cell volume homeostasis |
| Associated Diseases | Muscle weakness, Myotonia, neurodegeneration |
| Known Drugs/Compounds | NMD670 |
| Interactions | FKBP8, GSK3β, Hsp90β |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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