protein

CALBINDIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALBINDIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

6Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for Calbindin Protein

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🔬 Protein Info

Gene Symbol	CALBINDIN
Molecular Weight	30 kDa
Pathways	Neurogenesis
GeneCards	CALBINDIN
Human Protein Atlas	CALBINDIN
Six EF-hand domains	Four functional calcium-binding sites
N-terminal domain	Variable region affecting protein localization
C-terminal domain	Critical for dimerization
Hippocampus	CA1 pyramidal neurons, dentate gyrus granule cells, hippocampal interneurons
Cerebral Cortex	Layer 2-3 pyramidal neurons, specific interneuron populations
Cerebellum	Purkinje cells (most abundant expression)
Basal Ganglia	Striatal medium spiny neurons, cholinergic interneurons
Thalamus	Specific relay nuclei
Substantia Nigra	Dopaminergic neurons (some populations)
Excitotoxicity protection	Reduces NMDA receptor-mediated calcium toxicity
Known Drugs/Compounds	VANADIUM
Interactions	REELIN, VIMENTIN
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calbindin-Positive Neurons in Alzheimer's Disease

cell · 1226 words

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Pathway Diagram

graph TD
    CALBINDIN("CALBINDIN")
    Vanadium["Vanadium"]
    Vanadium -->|"downregulates"| CALBINDIN
    VANADIUM["VANADIUM"]
    VANADIUM -->|"inhibits"| CALBINDIN
    REELIN("REELIN")
    CALBINDIN -->|"activates"| REELIN
    Neurogenesis(["Neurogenesis"])
    CALBINDIN -->|"activates"| Neurogenesis
    Neuron["Neuron"]
    CALBINDIN -->|"activates"| Neuron
    NEURONS["NEURONS"]
    CALBINDIN -->|"activates"| NEURONS
    Differentiation["Differentiation"]
    CALBINDIN -->|"activates"| Differentiation
    INTERNEURONS["INTERNEURONS"]
    CALBINDIN -->|"activates"| INTERNEURONS
    GLUTAMATE["GLUTAMATE"]
    CALBINDIN -->|"interacts_with"| GLUTAMATE
    late{"late"}
    late -->|"activates"| CALBINDIN
    VIMENTIN("VIMENTIN")
    VIMENTIN -->|"interacts_with"| CALBINDIN

Outgoing (6)

Target	Relation	Type	Str
REELIN	activates	protein	0.50
Neurogenesis	activates	pathway	0.50
Neuron	activates	cell_type	0.50
NEURONS	activates	concept	0.50
INTERNEURONS	activates	concept	0.50
GLUTAMATE	interacts_with	concept	0.50

Incoming (4)

Source	Relation	Type	Str
Vanadium	downregulates	compound	0.85
VANADIUM	inhibits	drug	0.64
VIMENTIN	interacts_with	protein	0.50
late	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CALBINDIN in their description or question text

No additional research found