entity

Enteric nervous system dysfunction

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Enteric nervous system dysfunction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

1Hypotheses

1Analyses

2Outgoing

2Incoming

0Experiments

5Debates

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Outgoing (2)

Target	Relation	Type	Str
gut motility disruption	causes	phenotype	0.70
dysbiosis	causes	phenotype	0.70

Incoming (2)

Source	Relation	Type	Str
alpha-synuclein aggregation	causes	process	0.70
alpha_synuclein_aggregation	causes	phenotype	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Enteric Nervous System Dysfunction as Self-Reinforcing Patho	0.630	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation,

neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.630

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The Body, the Brain, the Environment, and Parkinson's Disease. [PMID:38607765]	["Dorsey E Ray", "De Miranda Briana R",	Journal of Parkinson's disease	2024
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogen [PMID:36455790]	Claudino Dos Santos JC, Lima MPP, Brito	Ageing Res Rev	2023
The microbiome-gut-brain axis in Parkinson disease - from basic research to the [PMID:35750883]	Tan AH, Lim SY, Lang AE	Nat Rev Neurol	2022
The role of gut dysbiosis in Parkinson's disease: mechanistic insights and thera [PMID:33856024]	Unknown	Brain : a journal of neurology	2021
Prion-like propagation of α-synuclein in the gut-brain axis. [PMID:29894766]	Unknown	Brain research bulletin	2019
Microbiome, Parkinson's Disease and Molecular Mimicry. [PMID:30866550]	Miraglia F, Colla E	Cells	2019
Brain-gut-microbiota axis in Parkinson's disease. [PMID:26457021]	["Mulak Agata", "Bonaz Bruno"]	World journal of gastroenterol	2015
Gut microbiota are related to Parkinson's disease and clinical phenotype. [PMID:25476529]	Scheperjans F, Aho V, Pereira PA	Mov Disord	2015

Debates (5)

Multi-agent debates referencing this entity

Hypothesis debate: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes

closed · Rounds: 4 · Score: 0.60 · 2026-04-26

Hypothesis debate: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propag

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Enteric Nervous System Dysfunction as Self-Reinforcing Pathol

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

What are the key molecular mechanisms by which gut microbiome dysbiosis drives n

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning Enteric nervous system dysfunction in their description or question text

No additional research found