Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about curli fibrils: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| alpha-synuclein aggregation | causes | mechanism | 0.70 |
| Vagal nerve fibers | propagates_via | pathway | 0.70 |
| SNCA | templates | gene | 0.70 |
| LRP1 | binds | protein | 0.70 |
| Brain parenchyma | enters | brain_region | 0.70 |
| Peripheral monocytes | phagocytosed_by | cell_type | 0.70 |
| ENS neurons | targets | cell_type | 0.70 |
| Alpha-synuclein aggregation | causes | process | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro | 0.642 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.907
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836] | Vinutha AS, Akshay S, Sree Agash SG, Cha | Archives of microbiology | 2026 | 0 |
| The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877] | Gurnani B, Jain N | The Journal of biological chem | 2026 | 0 |
| Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenera [PMID:40141340] | Singh AA, Khan F, Song M | International journal of molec | 2025 | 0 |
| E.coli-derived CsgA-peptides stimulate cytokine production in microglia and lead [PMID:41476670] | Mygind L, Jensen G, Neesgaard V, Krohn K | Brain, behavior, & immunity - | 2025 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Using Caenorhabditis elegans to Model Therapeutic Interventions of Neurodegenera [PMID:35571084] | Wang C, Zheng C | Frontiers in pharmacology | 2022 | 0 |
| Genome-wide screen identifies curli amyloid fibril as a bacterial component prom [PMID:34413194] | Wang C, Lau CY, Ma F, Zheng C | Proceedings of the National Ac | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |
| Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Pr [PMID:32538869] | Werner T, Horvath I, Wittung-Stafshede P | Journal of Parkinson's disease | 2020 | 0 |
| 7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Gl [PMID:33417205] | ["Nury T", "Yammine A", "Menetrier F", " | Advances in experimental medic | 2020 | 0 |
| Unified single-cell analysis of testis gene regulation and pathology in five mou [PMID:31237565] | Jung M, Wells D, Rusch J, Ahmad S, March | eLife | 2019 | 0 |
| Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parki [PMID:27912057] | ["Sampson TR", "Debelius JW", "Thron T", | Cell | 2017 | 0 |
| Anti-aging effects of coffee. [PMID:28854150] | Keita Takahashi; Akihito Ishigami | Aging | 2017 | 0 |
| The chronic myeloid leukemia stem cell: stemming the tide of persistence. [PMID:28159740] | Holyoake TL, Vetrie D | Blood | 2017 | 0 |
| Neurodegeneration in tauopathies and synucleinopathies. [PMID:27344208] | ["Foguem C", "Kamsu-Foguem B"] | Revue neurologique | 2016 | 0 |
| Three months of simvastatin therapy vs. placebo for severe portal hypertension i [PMID:26321186] | Pollo-Flores P, Soldan M, Santos UC, Kun | Digestive and liver disease : | 2015 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.84 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning curli fibrils in their description or question text
No additional research found