concept

AMYLOID_BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID_BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

1Hypotheses

1Analyses

16Outgoing

11Incoming

0Experiments

1Debates

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💡 Concept Info

Name	AMYLOID_BETA
Key Genes/Proteins	ANTIMICROBIAL_PEPTIDE, APP, BACTERIAL_AMYLOIDS, C3, CASPASE2, CYP46A1
Related Diseases	ALZHEIMER'S_DISEASE, CELL_DEATH, PLAQUES
Related Pathways	CA2_HOMEOSTASIS

Pathway Diagram

graph TD
    AMYLOID_BETA["AMYLOID_BETA"]
    AMYLOID_BETA -->|"contributes to"| PLAQUES["PLAQUES"]
    AMYLOID_BETA -->|"inhibits"| synaptic_plasticity["synaptic_plasticity"]
    AMYLOID_BETA -->|"regulates"| calcium["calcium"]
    AMYLOID_BETA -->|"activates"| NFKB["NFKB"]
    AMYLOID_BETA -->|"activates"| C3["C3"]
    AMYLOID_BETA -->|"inhibits"| CA2_HOMEOSTASIS["CA2_HOMEOSTASIS"]
    AMYLOID_BETA -->|"activates"| CASPASE2["CASPASE2"]
    AMYLOID_BETA -->|"causes"| CELL_DEATH["CELL_DEATH"]
    MICROGLIA["MICROGLIA"] -->|"interacts"| AMYLOID_BETA
    APP["APP"] -->|"regulates"| AMYLOID_BETA
    PRESENILIN["PRESENILIN"] -->|"regulates"| AMYLOID_BETA
    IGF1R["IGF1R"] -->|"inhibits"| AMYLOID_BETA
    ASK1["ASK1"] -->|"regulates"| AMYLOID_BETA

Outgoing (16)

Target	Relation	Type	Str
ds-6784494f1741	data_in	dataset	1.00
ds-b3d65f2c2ca6	provides_data_for	dataset	1.00
synapse loss	causes	phenotype	0.90
neurons	activates	cell_type	0.85
extracellular_vesicles	associated_with	pathway	0.80
ALZHEIMER'S_DISEASE	causes	disease	0.80
ANTIMICROBIAL_PEPTIDE	is	protein	0.80
Alzheimers_disease	associated_with	disease	0.72
PLAQUES	contributes_to	phenotype	0.72
CA2_HOMEOSTASIS	inhibits	pathway	0.64
CASPASE2	activates	protein	0.64
calcium	regulates	protein	0.64
NFKB	activates	protein	0.64
C3	activates	protein	0.64
synaptic_plasticity	inhibits	phenotype	0.64
CELL_DEATH	causes	phenotype	0.56

Incoming (11)

Source	Relation	Type	Str
ds-6784494f1741	data_in	dataset	1.00
ds-b3d65f2c2ca6	data_in	dataset	1.00
APP	expresses	gene	0.90
BACTERIAL_AMYLOIDS	induces_misfolding_of	protein	0.80
APP	regulates	gene	0.64
PRESENILIN	regulates	gene	0.64
MICROGLIA	interacts_with	cell_type	0.64
CYP46A1	associated_with	gene	0.60
ASK1	regulates	protein	0.56
IGF1R	inhibits	protein	0.56
MICRORNAS	interacts_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Amyloid-beta induces secondary pericyte senescence after con	0.640	neurodegeneration	Does pericyte senescence drive BBB break

Mentioning Analyses (1)

Scientific analyses that reference this entity

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.665

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which EV-derived biomarkers (phospho-tau, amyloid-beta, synaptic proteins, infla

closed · Rounds: 4 · Score: 0.75 · 2026-04-12

Related Research

Hypotheses and analyses mentioning AMYLOID_BETA in their description or question text

No additional research found