protein

VLDL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VLDL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

8Outgoing

11Incoming

0Experiments

0Debates

Summary

VLDL receptor protein in brain development, Reelin signaling, synaptic function, and Alzheimer's disease

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🔬 Protein Info

Gene Symbol	VLDL
Molecular Weight	105 kDa
Amino Acids	792 aa
Pathways	Cholesterol
GeneCards	VLDL
Human Protein Atlas	VLDL
Known Drugs/Compounds	ceramide
Interactions	APOE2, APOE3, APOE4, ERK, GPR146, LDL
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

VLDL Receptor

protein · 2760 words

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Pathway Diagram

graph TD
    VLDL(["VLDL"])
    GPR146["GPR146"]
    Cholesterol["Cholesterol"]
    SREBP2["SREBP2"]

    GPR146 -->|"regulates"| VLDL
    VLDL -->|"activates"| Cholesterol
    VLDL -->|"activates"| SREBP2
    GPR146 -->|"activates"| VLDL

    style VLDL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style GPR146 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style Cholesterol fill:#1a3a1a,stroke:#81c784,stroke-width:2px,color:#fff
    style SREBP2 fill:#1a1a2e,stroke:#ffd54f,stroke-width:2px,color:#fff

Outgoing (8)

Target	Relation	Type	Str
Triglyceride Transport	mediates	process	0.85
Ceramide	transports	compound	0.80
ceramide	interacts_with	compound	0.80
blood-brain barrier	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.55
Cholesterol	activates	pathway	0.50
SREBP2	activates	concept	0.50

Incoming (11)

Source	Relation	Type	Str
GPR146	regulates	protein	0.64
ERK	activates	gene	0.60
LDL	activates	gene	0.60
SREBP2	activates	gene	0.60
LDL	associated_with	gene	0.60
APOE2	interacts_with	gene	0.55
APOE3	interacts_with	gene	0.55
APOE4	interacts_with	gene	0.55
GPR146	co_expressed_with	gene	0.50
LDLR	co_expressed_with	gene	0.50
GPR146	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VLDL in their description or question text

No additional research found