Contents

FUS-Targeting Therapies for Amyotrophic Lateral Sclerosis

🔬 Protein Info

Gene Symbol	FUS
Full Name	Targeting Therapies for Amyotrophic Lateral Sclerosis
Chromosome	16p11.2.
Protein Type	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	Blood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt ID	Search UniProt
GeneCards	FUS
Human Protein Atlas	FUS
N-terminal low-complexity (LC) domain	Involved in liquid-liquid phase separation and stress granule formation[@kato2012]
RNA recognition motif (RRM)	Binds RNA with sequence specificity[@lerga2001]
Multiple zinc finger motifs	Mediates protein-protein interactions[@dormann2010]
C-terminal prion-like domain	Facilitates aggregation propensity[@king2012]
RNA processing	Alternative splicing, transcription regulation, and RNA transport[@vance2009]
DNA damage response	FUS recruitment to DNA damage sites[@britton2014]
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ADUCANUMAB, Antisense Oligonucleotide, Rna Oligonucleotides, RNA oligonucleotides
Interactions	ACTB, Actin, AD, AGING, ALPHA-SYNUCLEIN, ALS
SciDEX Hypotheses	ASO-Mediated Exon Skipping to Restore FUS-TAZ Chap FUS Mutations Alter Stress Granule Material Proper FUS Mutations Impede G3BP1's Chaperone Function, E
KG Connections	1547 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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