protein 2,181 words KG: PCNAPROTEIN
Contents

PCNA Protein (Proliferating Cell Nuclear Antigen)

🔬 Protein Info
Gene SymbolPCNA
AliasesProliferating Cell Nuclear Antigen
FunctionBeyond its canonical roles in DNA replication, PCNA has been implicated in various neurodegenerative diseases, particularly those involving DNA repair dysfunction and replicative stress.
Molecular Weight28.8 kDa
GeneCardsPCNA
Human Protein AtlasPCNA
Associated DiseasesALS
Known Drugs/Compoundsrapamycin
InteractionsAKT, APC, ATG, BCL-2, BCL2, CASPASE3
KG Connections72 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (8)

Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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