protein 1,671 words KG: NEFLPROTEIN
Contents

Neurofilament Light Chain Protein

🔬 Protein Info
Gene SymbolNEFLPROTEIN
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization| Neuronal axon (cytoskeleton) |- \! Protein Family | Type IV intermediate filam
Amino Acids543 aa
GeneCardsNEFLPROTEIN
Human Protein AtlasNEFLPROTEIN
Associated DiseasesAlzheimers_disease
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, BCL2, BNIP3L, C9ORF72, CNR1
SciDEX HypothesesPlasma NfL Elevation Secondary to BBB-Associated T
Plasma NfL Elevation Secondary to BBB-Associated T
KG Connections197 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (71)

CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Flotillin-1 Stabilization Compounds
Score: 0.68
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Netrin-1 Gradient Restoration
Score: 0.59
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Related Analyses (24)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (17)

ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Axonal Transport Dysfunction Validation in Parkinson's Disea
clinical · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40

See Also (15)

China Neurodegeneration Epidemiology
disease · Pages share 68 hypotheses
Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 68 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 68 hypotheses
Swedish BioFINDER 2 Study: Biomarkers and Neurodegenera
clinical · Pages share 68 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 68 hypotheses

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