protein 1,671 words KG: NEFLPROTEIN
Contents

Neurofilament Light Chain Protein

🔬 Protein Info
Gene SymbolNEFLPROTEIN
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization| Neuronal axon (cytoskeleton) |- \! Protein Family | Type IV intermediate filam
Amino Acids543 aa
GeneCardsNEFLPROTEIN
Human Protein AtlasNEFLPROTEIN
Associated DiseasesAlzheimers_disease
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, BCL2, BNIP3L, C9ORF72, CNR1
SciDEX HypothesesPlasma NfL Elevation Secondary to BBB-Associated T
Plasma NfL Elevation Secondary to BBB-Associated T
KG Connections197 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (71)

Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Ocular Immune Privilege Extension
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
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Related Analyses (24)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (17)

ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Axonal Transport Dysfunction Validation in Parkinson's Disea
clinical · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40

See Also (15)

China Neurodegeneration Epidemiology
disease · Pages share 68 hypotheses
Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 68 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 68 hypotheses
Swedish BioFINDER 2 Study: Biomarkers and Neurodegenera
clinical · Pages share 68 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 68 hypotheses

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