| Gene Symbol | NCSTNPROTEIN |
| Protein Type | Protease |
| Function | is an essential subunit of the γ-secretase complex that cleaves amyloid precursor protein (APP) and Notch receptors. |
| Subcellular Localization | ** | Plasma membrane, endosomes, Golgi | |
| Molecular Weight | 130 kDa |
| Amino Acids | 709 aa |
| GeneCards | NCSTNPROTEIN |
| Human Protein Atlas | NCSTNPROTEIN |
| DAP domain | Peptidase-like domain that recognizes free N-termini of γ-secretase substrates |
| Lid domain | Covers the active site region; opens to admit substrates |
| Single transmembrane helix | Anchors nicastrin in the membrane; interacts with APH-1 |
| N-glycosylation | 16 potential N-glycosylation sites; heavy glycosylation critical for maturation and surface expression |
| N-terminus recognition | Nicastrin's Glu333 (DAP domain) recognizes the free N-terminal stub of substrates after ectodomain shedding (by α- or β-secretase) |
| Size filter | Ectodomain acts as a molecular ruler — only substrates with short (<50 aa) residual ectodomains can access the presenilin active site |
| No enzymatic activity | Despite structural similarity to aminopeptidases, nicastrin has no catalytic activity |
| Associated Diseases | AD, Als, Alzheimer, Alzheimer's disease, AMI |
| Interactions | A2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APH1B |
| KG Connections | 191 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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