protein 606 words KG: LRP4
Contents

LRP4 Protein

🔬 Protein Info
Gene SymbolLRP4
AliasesPage for LRP4 Protein
Chromosome11p11.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight195 kDa
Amino Acids1725 aa
Exons33
PathwaysWnt signaling, Wnt
UniProt ID[Q9NPJ6](https://www.uniprot.org/uniprot/Q9NPJ6)
Ensembl IDENSG00000134538
GeneCardsLRP4
Human Protein AtlasLRP4
Agrin bindingBinds neuronal agrin at the neuromuscular junction
AChR clusteringInitiates and maintains acetylcholine receptor clusters
Associated DiseasesAging, Als, Atherosclerosis, Cancer, Cardiovascular
InteractionsCANCER, PAH, WNT
KG Connections68 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (7)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (8)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

LDLR Gene
gene · KG edge: associated_with
LRP1B — Low Density Lipoprotein Receptor-Related Protei
gene · KG edge: associated_with
LRP2 — Low Density Lipoprotein Receptor-Related Protein
gene · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
LRP1-Enhanced Perivascular Drainage Therapy
idea · KG edge: associated_with

Knowledge Graph (12 edges)

LRP8 associated_with LRP4
LRP5 associated_with LRP4
LRP1 associated_with LRP4
LRP2 associated_with LRP4
LRP1B associated_with LRP4
LRP4 associated_with PAH
LRP4 associated_with LDLR
PAH associated_with LRP4
LRP4 associated_with LRP5
LRP4 associated_with LRP1

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