| Gene Symbol | LRP1 |
| Aliases | Low-density lipoprotein receptor-related protein 1, CD91 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | In the healthy nervous system, LRP1 functions as |
| Mechanism of Action | Modulation of receptor-mediated endocytosis and clearance pathways |
| Druggability | Low (0.39) |
| Clinical Stage | Phase III |
| Molecular Weight | 600 kDa |
| Amino Acids | 525 aa |
| Pathways | Aβ clearance, APOE trafficking, Endocytosis, MAPK, PI3K |
| UniProt ID | Q07954 |
| GeneCards | LRP1 |
| Human Protein Atlas | LRP1 |
| Extracellular α chain | Contains 31 ligand-binding complement-type repeats organized in four clusters |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | MELATONIN |
| Interactions | ABCA1, abca2, ABCA2, ABCB1, ABI3, ACAT1 |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | LRP1-Dependent Tau Uptake Disruption Astrocyte LRP1-mediated tau uptake and APOE4-depen LRP1-Dependent Tau Uptake Disruption (+4 more) |
| KG Connections | 1655 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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