| Gene Symbol | LGALS3 |
| Full Name | Lectin, Galactoside-Binding, Soluble, 3 |
| Aliases | LGALS3PROTEIN |
| Chromosome | 14 |
| Function | The LGALS3 gene encodes Lectin, Galactoside-Binding, Soluble, 3, a protein expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum. |
| Primary Expression | activated microglia and plays complex roles in neuroinflammation - both promoting and resolving inflammatory responses |
| Pathways | Amyloid, Lipid Metabolism |
| UniProt ID | P17931 |
| Ensembl ID | ENSG00000131981 |
| OMIM | 153619 |
| GeneCards | LGALS3 |
| Human Protein Atlas | LGALS3 |
| Neurons | Low constitutive expression |
| Astrocytes | Moderate expression, increased in reactive astrocytes |
| Microglia | Very low in resting microglia, highly upregulated upon activation |
| Associated Diseases | AD, ALI, Als, Alzheimer, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | rapamycin |
| Interactions | ABCD3, ACTB, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE |
| SciDEX Hypotheses | Galectin-3 deletion attenuates NLRP3 inflammasome Lectin-Mediated Autophagy Enhancers Galectin-3 as Damage-Sensor Scaffold for Multimeri |
| KG Connections | 944 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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