| Gene Symbol | HCN4 |
| Full Name | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4 |
| Chromosome | 15q24.1 |
| Protein Type | Channel |
| Function | is a transmembrane protein that forms homotetrameric ion channels. |
| Primary Expression | various brain regions where it contributes to neuronal excitability, rhythmic activity, and synaptic integration |
| Subcellular Localization | Cell membrane (plasma membrane), dendrites, axon initial segment |
| Amino Acids | 919 aa |
| UniProt ID | Q9Y3X5 |
| NCBI Gene ID | 80216 |
| Ensembl ID | ENSG00000138668 |
| OMIM | 607272 |
| GeneCards | HCN4 |
| Human Protein Atlas | HCN4 |
| Slowest activation kinetics | HCN4 activates more slowly than HCN1-3 |
| Associated Diseases | Absence Seizures, AD, Als, AMI, ARM |
| Interactions | AND, App, EPILEPSY, GENES, HCN, JUN |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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